%0 Journal Article
%A Dumitrașcu, Anda Dumitrașcu
%A Paduraru, Dan Nicolae Paduraru
%A Valea, Ana Valea
%A Carsote, Mara Carsote
%D 2020
%J Central European Annals of Clinical Research

%@ 2668-7305

%V 2
%N 2
%P 15

%T Osteogenesis Imperfecta-Related Osteoporosis: Between Low Bone Mineral Density and Multiple Fractures
%M doi:10.35995/ceacr2010015
%U https://ceacr.archive.jams.pub/article/2/2/86
%X Osteoporosis is reflected by low bone mineral density (BMD) at central Dual-Energy X-ray Absorptiometry (DXA) as well as clinical complications like low-trauma or spontaneous fractures. While typical primary osteoporosis is menopause-related, among the secondary causes of osteoporosis, osteogenesis imperfecta (OI) is listed for children, teenagers and adults. Underlining more than 17 mutations, and a heterogeneous clinical presentation, decreased BMD is associated with multiple fractures and impaired peak bone mass with lifelong effects.